Human RZZ kinetochore corona complex.
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7qpg
Q-score: 0.202
Raisch T, Ciossani G, d'Amico E, Cmentowski V, Carmignani S, Maffini S, Merino F, Wohlgemuth S, Vetter IR, Raunser S, Musacchio A
EMBO J (2022) 41 pp. e110411-e110411 [ Pubmed: 35373361 DOI: doi:10.15252/embj.2021110411 ]
- Kinetochore-associated protein 1 (279 kDa, Protein from Homo sapiens)
- Protein zwilch homolog (67 kDa, Protein from Homo sapiens)
- Centromere/kinetochore protein zw10 homolog (88 kDa, Protein from Homo sapiens)
- Rzz complex (Complex from Homo sapiens)
Structure of the P. aeruginosa ExoY-F-actin complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7p1g
Q-score: 0.46
Belyy A, Merino F, Mechold U, Raunser S
Nat Commun (2021) 12 pp. 6628-6628 [ DOI: doi:10.1038/s41467-021-26889-2 Pubmed: 34785651 ]
- Phalloidin (808 Da, Protein from Amanita phalloides)
- The complex of p. aeruginosa exoy with f-actin (Complex)
- 3'-deoxy-guanosine-5'-triphosphate (507 Da, Ligand)
- Maltose/maltodextrin-binding periplasmic protein,adenylate cyclase exoy (84 kDa, Protein from Pseudomonas aeruginosa PAO1)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Actin, alpha skeletal muscle (42 kDa, Protein from Rabbit)
- Magnesium ion (24 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
Structure of the V. vulnificus ExoY-G-actin-profilin complex
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7p1h
Q-score: 0.264
Belyy A, Merino F, Mechold U, Raunser S
Nat Commun (2021) 12 pp. 6628-6628 [ DOI: doi:10.1038/s41467-021-26889-2 Pubmed: 34785651 ]
- Maltose/maltodextrin-binding periplasmic protein,rtx-toxin (91 kDa, Protein from Vibrio vulnificus)
- Calcium ion (40 Da, Ligand)
- Profilin-1 (15 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Structure of the v. vulnificus exoy-g-actin-profilin complex (Complex)
- Actin, cytoplasmic 1 (41 kDa, Protein from Homo sapiens)
Structure of capping protein bound to the barbed end of a cytoplasmic actin filament
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7pdz
Q-score: 0.333
Funk J, Merino F, Schaks M, Rottner K, Raunser S, Bieling P
Nat Commun (2021) 12 pp. 5329-5329 [ DOI: doi:10.1038/s41467-021-25682-5 Pubmed: 34504078 ]
- Actin, cytoplasmic 1 (41 kDa, Protein from Bovine)
- Isoform 2 of f-actin-capping protein subunit beta (30 kDa, Protein from Mus musculus)
- Complex between capping protein and the barbed end of cytoplasmic actin filaments (Complex)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Phalloidin (808 Da, Protein from synthetic construct)
- Magnesium ion (24 Da, Ligand)
- F-actin-capping protein subunit alpha-1 (32 kDa, Protein from Mus musculus)
- Phosphate ion (94 Da, Ligand)
TRPC4 in complex with inhibitor GFB-8749
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7b05
Q-score: 0.476
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Trpc4 in complex with inhibitor gfb-8749 (108 kDa, Complex from Danio rerio)
- 4-[4-[[4,4-bis(fluoranyl)cyclohexyl]methyl]-3-oxidanylidene-piperazin-1-yl]-5-chloranyl-1~{h}-pyridazin-6-one (360 Da, Ligand)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7b0j
Q-score: 0.581
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Trpc4 membrane protein (108 kDa, Cellular component from Danio rerio)
- Calcium ion (40 Da, Ligand)
TRPC4 in complex with inhibitor GFB-8438
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7b0s
Q-score: 0.501
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- Trpc4 in complex with inhibitor gfb-8438 (108 kDa, Cellular component from Danio rerio)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 5-chloranyl-4-[3-oxidanylidene-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]-1~{h}-pyridazin-6-one (386 Da, Ligand)
TRPC4 in complex with inhibitor GFB-9289
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7b16
Q-score: 0.563
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 5-chloranyl-4-(4-cyclohexyl-3-oxidanylidene-piperazin-1-yl)-1~{h}-pyridazin-6-one (310 Da, Ligand)
- Trpc4 in complex with inhibitor gfb-9289 (108 kDa, Cellular component from Danio rerio)
TRPC4 in complex with Calmodulin
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7b1g
Q-score: 0.489
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- Calmodulin-1 (16 kDa, Protein from Mus musculus)
- Transient receptor potential cation channel subfamily c member 4a (Cellular component from Danio rerio)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- Calmodulin-1 (Cellular component from Mus musculus)
- Calcium ion (40 Da, Ligand)
- Trpc4 membrane protein in complex with calmodulin (126 kDa, Cellular component)